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Intrathecal drug delivery 

Intrathecal drug delivery
Chapter:
Intrathecal drug delivery
Author(s):

L. Lynch

DOI:
10.1093/med/9780199586912.003.0010
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date: 02 March 2021

Intrathecal drug delivery 158

Drugs 160

Patient selection 166

Types of ITDD system 168

Test doses and trials 172

Complications 174

Implant technique 176

Postoperative management 180

Infusion regimens and management post-implant 182

Trouble-shooting 184

Case studies 186

Intrathecal drug delivery (ITDD) has been an option for the management of persistent pain since the 1980s. The discovery of opioid receptors in the central nervous system in 1976 was the impetus for early attempts to deliver opioids intraspinally....

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