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Risperidone long-acting injection* 

Risperidone long-acting injection*
Risperidone long-acting injection*

Pierre Chue

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date: 17 June 2019

Risperidone is a second-generation (SGA) or atypical (novel) antipsychotic first marketed worldwide in the 1990s as an oral preparation. In 2003, the US Federal Drugs Administration (FDA) approved risperidone long-acting injection (RLAI), the first SGA to be available commercially in an injectable sustained-action formulation (Chue 2003; Ereschefsky & Mascarenas 2003). This chapter describes the development of RLAI, reviews aspects of the pharmacokinetics, summarizes the pivotal trials and clinical data including pharmacoeconomic, and discusses the potential future directions for this novel formulation.

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