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Nephrogenic systemic fibrosis 

Nephrogenic systemic fibrosis
Nephrogenic systemic fibrosis

Teresa K. Chen

and Derek M. Fine

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date: 05 August 2020

1. NSF can be a devastating disorder resulting in excruciating pain and/or severe disability.

2. Gadolinium triggers NSF.

3. Not all GBC agents are created equal. Risk of NSF is dependent on the individual stability of each GBC agent.

4. The prolonged half-life of GBC agents in renal failure (GFR <30 ml/min/1.73m2) predisposes to NSF by allowing for dissociation of toxic free gadolinium.

5. The deposition of gadolinium in tissue triggers a cascade of events culminating in the clinical presentation of NSF.

6. Treatments for NSF are limited and still being investigated. Until then, our best defence against NSF is prevention.

7. For those with NSF, physical and occupational therapy are critical in maintaining functional status.

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