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Rheumatological diseases associated with interstitial nephritis 

Rheumatological diseases associated with interstitial nephritis
Rheumatological diseases associated with interstitial nephritis

Alan D. Salama

and Charles D. Pusey

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date: 26 October 2020

1. Renal involvement may occur in a number of rheumatological conditions. It may be asymptomatic and its timely diagnosis requires clinical vigilance.

2. Urinalysis should be performed regularly in all patients with rheumatic disease and proteinuria quantified by spot protein-to- (not albumin) creatinine ratio.

3. Renal biopsy remains the only definite way to diagnose TIN and in experienced hands is a safe procedure.

4. Treatment of TIN associated with rheumatic disease has generally relied on corticosteroids, with other therapy being dictated by concurrent glomerular lesions. These recommendations come from small cohort series and not from randomized studies.

5. The factors regulating resolution or progression of disease remain poorly defined.

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