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Hepatitis B-associated renal diseases 

Hepatitis B-associated renal diseases
Chapter:
Hepatitis B-associated renal diseases
Author(s):

Kar Neng Lai

and Sydney C.W. Tang

DOI:
10.1093/med/9780199579655.003.0123
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date: 09 August 2020

1. HBV-related glomerulopathy is associated with chronic immune complex formation in situ.

2. The pathologies include MN, mesangiocapillary nephropathy and mesangial proliferative GN with IgA deposits.

3. The development of individual pathology is related to the size of the HBV antigens.

4. The glomerulopathy progresses slowly with development of end-stage renal failure if untreated.

5. Anti-viral agents are effective in slowing the progression of the renal failure. Symptomatic improvement occurs with eradication of the virus

6. Prevention by an effective vaccination programme is far superior to anti-viral treatment despite the fact that new anti-viral therapy is promising on a long-term carrier.

7. A national vaccination for newborn in endemic areas is strongly recommended.

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