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Polyarteritis nodosa: Clinical characteristics, outcome, and treatment 

Polyarteritis nodosa: Clinical characteristics, outcome, and treatment
Polyarteritis nodosa: Clinical characteristics, outcome, and treatment

Loïc Guillevin

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date: 22 October 2020

Polyarteritis nodosa (PAN) was the first vasculitis to be described by Küssmaul and Maier. For many years what are now known to be distinct vasculitides were then considered together under the term PAN. The last to be separated from PAN were Churg–Strauss syndrome, a vasculitis occurring in asthmatic patients, and microscopic polyangiitis (MPA), individualized from PAN by Wohlwill then redefined by Davson et al. Today, PAN is a well-defined vasculitis that affects medium sized vessels. Considering PAN aetiologies, primary and secondary forms can also be discerned, as PAN can be the consequence of hepatitis B virus (HBV) infection, and sometimes of other aetiological agents. In this chapter, we review the main characteristics of PAN, its outcome and treatment. PAN histology and pathogenesis have been extensively detailed in other chapters of this book.

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