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Vasculitis classification 

Vasculitis classification
Vasculitis classification

J. Charles Jennette

, Ronald J. Falk

, and Adil Hussein Gasim

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date: 20 September 2020

1. Because many different vasculitides can produce indistinguishable features, one should be cautious not to rush to conclusions based on the first bits of evidence. For example, purpura with nephritis in a child is most likely Henoch–Schönlein purpura (IgA vasculitis), but could be microscopic polyangiitis, cryoglobulinaemic vasculitis or other small vessel vasculitides.

2. Diagnostic categorization of vasculitis is a complex process that requires knowledgeable integration of clinical, laboratory and pathological data. For example, serological testing for autoimmune and infectious diseases often provides useful data.

3. Carefully consider not only what features are present, but also, equally important, what features are absent. For example, both the presence and the absence of  hypocomplementaemia, cryoglobulins, ANCA, blood eosinophilia, hepatitis antibodies and other laboratory abnormalities allows narrowing of the differential diagnosis in a patient with evidence for systemic vasculitis.

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