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Systemic lupus erythematosus (SLE) in pregnancy 

Systemic lupus erythematosus (SLE) in pregnancy
Chapter:
Systemic lupus erythematosus (SLE) in pregnancy
Author(s):

Aisha Lateef

and M. Petri

DOI:
10.1093/med/9780199579655.003.0038
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date: 05 August 2020

1. Pregnancy in SLE is associated with increased maternal and foetal morbidity including disease flares, foetal loss, prematurity, IUGR and pre-eclampsia.

2. Disease flares are more common during pregnancy.

3. Disease activity at the time of conception is associated with poor outcomes.

4. Pre-conception assessment is necessary to risk-stratify the patients.

5. Differentiation between renal flares and pre-eclampsia may be difficult in some cases.

6. Pre-term births are frequent in SLE pregnancies. The combination of highly active clinical lupus and abnormal serological tests (low complement, high anti-dsDNA) is most predictive of pre-term birth.

7. Pharmacotherapy during pregnancy needs to be adjusted for the safety of the mother and foetus.

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