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The role of biologicals in the treatment of lupus nephritis 

The role of biologicals in the treatment of lupus nephritis
Chapter:
The role of biologicals in the treatment of lupus nephritis
Author(s):

Amara N. Ezeonyeji

and David A. Isenberg

DOI:
10.1093/med/9780199579655.003.0035
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date: 23 September 2020

1. Over the last few years, treatment of SLE and LN has moved from serendipity to immunological sense focusing on biological agents that target the cells and molecules specifically involved in the critical pathways in SLE pathogenesis.

2. Biological agents offer the possibility of efficacious and safe treatment options for patients with refractory disease, reducing the burden of immunosuppressive drugs.

3. In spite of some recent disappointing results with biological, including abatacept and rituximab, a number of newer agents have shown encouraging benefits.

4. Belumimab and epratuzumab have both met their primary end-points in the BLISS-52, BLISS-76 and epratuzumab phase IIb trials, and rontalizumab and tociluzumab have shown promising results in phase I studies.

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