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Evidence-based treatment of lupus nephritis 

Evidence-based treatment of lupus nephritis
Evidence-based treatment of lupus nephritis

Wai Y. Tse

and Dwomoa Adu

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date: 29 September 2020

1. A summary of the recommendations of the management of SLE is shown in Table 5.1.

2. Complications of drug treatment account for much of the morbidity that develops in SLE, in particular complications of high-dose or chronic corticosteroids (infection, osteonecrosis, osteoporosis, coronary artery disease) and cyclophosphamide (infection, sterility, bladder toxicity and malignancy).

3. It is encouraging that mycophenolate mofetil has a less toxic side effect profile than cyclo-phosphamide.

4. The risk of infections is substantial in patients taking corticosteroids and immuno-suppressants.

5. Regular clinical review of the patient's condition, together with laboratory tests and urinalysis to detect marrow depression, disease activity or progressive disease is mandatory in the management of these patients.

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