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Unsealed sources for therapy 

Unsealed sources for therapy
Chapter:
Unsealed sources for therapy
Author(s):

S J Chittenden

, G Flux

, and B Pratt

DOI:
10.1093/med/9780199573356.003.0155
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date: 15 October 2019

Unsealed sources of radioactivity have been used for therapy for over 60 years. They are usually administered in liquid form orally, by intravenous infusion or by direct injection into tumours or body cavities. Capsules containing radioactive iodine are also frequently given orally. The term ‘systemic radionuclide therapy’ is where the radioactivity is not confined to a tumour or cavity during treatment and implies that the whole body is irradiated. The success of treatment partly depends on how well radioactivity is concentrated and retained in the tumour(s) in preference to the normal tissues. The term ‘targeted radionuclide therapy’ is when the activity is preferentially accumulated in the tumour(s) either due to direct administration or by selective uptake of the radiopharmaceutical due to biological or chemical processes....

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