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BPH, PSA, and the risk of having prostate cancer (PCA) 

BPH, PSA, and the risk of having prostate cancer (PCA)
Chapter:
BPH, PSA, and the risk of having prostate cancer (PCA)
Author(s):

Seife Hailemariam

and Lukas Bubendorf

DOI:
10.1093/med/9780199572779.003.0004
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date: 20 September 2020

Benign prostatic hyperplasia (BPH) is a common benign disorder of the prostate that, when advanced, results in varying degrees of urinary obstruction with lower urinary tract symptoms (LUTS)

The disease represents a nodular enlargement of the prostate mainly in the transition zone (TZ) caused by hyperplasia of both glandular and stromal components

It occurs only in individuals with intact testes indicating androgen dependency

Despite topographic and architectural similarities between PCA arising in TZ and atypical adenomatous hyperplasia (AAH) and BPH, there is no convincing evidence linking BPH or AAH to PCA.

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