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Specific therapies for PAH 

Specific therapies for PAH
Chapter:
Specific therapies for PAH
Author(s):

Clive Handler

and Gerry Coghlan

DOI:
10.1093/med/9780199572564.003.032
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date: 17 October 2019

Supportive medical therapies in PAH 210

Advanced therapies for PAH 212

Classes of recommendations for procedures and treatments 218

Drug interactions with PAH targeted therapies 219

Combination therapy in PAH 220

Problems in conducting PAH drug trials 222

Surgical interventions 225

Anticoagulation, usually warfarin, is recommended for most patients with PAH. The rationale is based on the high frequency of thrombotic lesions in postmortem studies, the observed prothrombotic coagulation abnormalities, abnormalities in the fibrinolytic and coagulation pathways, and endothelial abnormalities, and the general prothrombotic factors—immobility and heart failure, which increase the risk of thromboembolism. Indwelling catheters for administration of prostanoids may increase the risk of local clotting and VTE, and anticoagulation is recommended for these patients....

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