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Pathology of PH due to lung diseases and/or hypoxia 

Pathology of PH due to lung diseases and/or hypoxia
Pathology of PH due to lung diseases and/or hypoxia

Clive Handler

and Gerry Coghlan

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date: 30 September 2020

Pathology of PH due to lung diseases and/or hypoxia 34

Medial hypertrophy and intimal obstructive proliferation of the distal PAs. In emphysema and lung fibrosis, the vascular bed is affected.

In advanced lung disease, the loss of capillary cross-sectional area is believed to be responsible for PH, although this has not been confirmed on histological evaluation, and there is a very poor relationship between the extent of lung destruction and the severity of PH. While there have been some observations of medial thickening as in PAH, this is generally quite mild, hence there is no rational basis for treating these patients with PAH therapies....

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