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Pharmacological approaches to depression 

Pharmacological approaches to depression
Pharmacological approaches to depression

Roger S. McIntyre

and Jay Nathanson

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date: 18 October 2019

Tricyclic antidepressants have been the conventional standard of efficacy in severe depression

Conventional pharmacotherapy (e.g., second- and later- generation antidepressants) offer efficacy in the treatment of MDD

Placebo response rates in severe depression have been consistently lower when compared to mild-moderate depression

The majority of individuals with severe depression will not achieve and/or sustain remission with antidepressant monotherapy

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