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Defining severe depression 

Defining severe depression
Defining severe depression

Roger S. McIntyre

and Jay Nathanson

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date: 22 October 2019

Currently, no consensually agreed-upon definition of “severe depression” exists

HAMD-17 and MADRS scores of 28–30 and 30+, respectively, are the most often utilized definitions of severe depression

The appellation “severe depression” is often employed imprecisely and interchangeably with treatment-resistant and chronic depression

Essential features of the definition of severe depression have included: symptom severity, severity dimensions (e.g., melancholia) and symptom status.

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