Show Summary Details
Page of

Autoantibodies and lupus nephritis 

Autoantibodies and lupus nephritis
Autoantibodies and lupus nephritis

Anisur Rahman

, Jessica J. Manson

, and David A. Isenberg

Page of

PRINTED FROM OXFORD MEDICINE ONLINE ( © Oxford University Press, 2016. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 20 November 2019

Lupus nephritis is a strikingly heterogeneous condition. This heterogeneity is exemplified in the role played by autoantibodies. Serological studies provide evidence that a number of different antibodies may be linked to the occurrence of renal involvement in patients with SLE, but some are only important in a small subset of patients. Anti-dsDNA antibodies are the most commonly seen antibodies in lupus nephritis, and those for which evidence of a pathogenic role is strongest. However, some anti-dsDNA negative patients have nephritis in association with anti-ssDNA or anti-Ro. Conversely, not all patients with high titers of anti-dsDNA develop nephritis. This shows that only a subset of anti-dsDNA antibodies are nephritogenic, and factors important in defining this subset are likely to include affinity, specificity, isotype, idiotype, and an ability to cross-react with cell-surface antigens. These nephritogenic antibodies can exert their effects on the glomeruli by different mechanisms. These include binding to DNA attached to collagen, binding to cell-surface proteins, and binding of anti-DNA/DNA/histone complexes to HS in the GBM. In any one patient, a number of different mechanisms may be operating and their relative importance is likely to vary from case to case. Thus, the task of finding a specific form of therapy directed against autoantibodies is a challenging one.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.