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Venous Thromboembolism 

Venous Thromboembolism
Venous Thromboembolism

Sebastian M. Schellong

, Henri Bounameaux

, and Harry R. Büller

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date: 24 September 2021

In this chapter, deep vein thrombosis (DVT) and pulmonary embolism (PE) are discussed as manifestations of the same disease process. Despite the steadily growing use of medical thromboprophylaxis, PE remains the third most frequent cause of cardiovascular mortality.

The current concept of venous thromboembolism (VTE) is that of a multifactorial disease. Besides age, several transient and permanent risk factors have been recognized. The strongest in the former group are surgery and trauma, whereas the latter is dominated by active cancer and thrombophilia. However, a substantial proportion of cases present without an identifiable risk factor and are therefore classified as ‘idiopathic’ or ‘unprovoked’ episodes. In those patients, or in the presence of a permanent risk factor, VTE is a chronic relapsing disease....

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