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Clinical Pharmacology of Cardiovascular Drugs 

Clinical Pharmacology of Cardiovascular Drugs
Chapter:
Clinical Pharmacology of Cardiovascular Drugs
Author(s):

Faiez Zannad

, Pascal Bousquet

, and Laurent Monassier

DOI:
10.1093/med/9780199566990.003.011
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date: 22 August 2019

Treatment of cardiovascular (CV) disease often requires the administration of numerous medications for long periods of time to patients likely to be old and suffering from a range of comorbid conditions. Rational prescribing informed by clinical pharmacology is essential if the right drug is to be administered to the right patient, at the right time, and for the right price. This requires an appreciation of the key principles of clinical pharmacology, and specific knowledge of individual therapies. Knowledge of polypharmacy and drug interactions is crucial, and the pharmacokinetic and pharmacodynamic challenges associated with advanced patient age, comorbidity, and sometimes frailty must be addressed and overcome. The environmental and genetic determinants of variability in response to treatment are increasingly well understood, and new biomarkers and pharmacogenetic techniques provide the foundations of the emerging discipline of personalized medicine. Long-term preventive medication raises issues concerning safety, adherence, and cost to healthcare providers. A basic familiarity with the principles of pharmaco-vigilance, pharmaco-epidemiology, and pharmaco-economics may therefore be of some value to practitioners....

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