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Drug synergy and sequencing 

Drug synergy and sequencing
Drug synergy and sequencing

Michael I. Bennett

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date: 23 June 2021

Combinations of drugs that work through different mechanisms can result in additive or synergistic effects that may improve control of pain, reduce side-effects, or both

Most evidence comes from studies of co-analgesics with opioids and is derived from both animal and clinical research

Although number needed to treat (NNT) is used to compare drug effectiveness, this method may miss some benefits, overestimate reliability (if confidence intervals are wide), and may detract from number needed to harm (NNH)...

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