Show Summary Details
Page of

Drug synergy and sequencing 

Drug synergy and sequencing
Chapter:
Drug synergy and sequencing
Author(s):

Michael I. Bennett

DOI:
10.1093/med/9780199563678.003.0018
Page of

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). © Oxford University Press, 2020. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 05 December 2020

Combinations of drugs that work through different mechanisms can result in additive or synergistic effects that may improve control of pain, reduce side-effects, or both

Most evidence comes from studies of co-analgesics with opioids and is derived from both animal and clinical research

Although number needed to treat (NNT) is used to compare drug effectiveness, this method may miss some benefits, overestimate reliability (if confidence intervals are wide), and may detract from number needed to harm (NNH)...

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.