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Ketamine and other NMDA receptor antagonists 

Ketamine and other NMDA receptor antagonists
Chapter:
Ketamine and other NMDA receptor antagonists
Author(s):

Marie Fallon

, Cameron Fergus

, and Barry J.A. Laird

DOI:
10.1093/med/9780199563678.003.0013
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date: 26 May 2020

Ketamine is a non-competitive N-methyl D-aspartate (NMDA) receptor antagonist and is most effective in pain states where hyper-excitability is established

Ketamine undergoes first-pass metabolism to norketamine, which is a more potent analgesic than ketamine. This can explain why oral ketamine is more potent than parenteral ketamine...

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