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Richards Duncan

, Jamie Coleman

, John Reynolds

, and Jeffrey Aronson

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date: 10 July 2020


Antihistamines BNF 3.4.1, 13.5.1, 11.4.2, 4.6, and 12.2.1 688


Retinoids BNF 13.6.1, 8.1.5, 13.5.2 and 13.8.1 692

Antagonists at H1 histamine receptors

A structurally diverse group of drugs sharing the ability to block the H1 histamine receptor. Histamine causes bronchoconstriction, increases bowel peristalsis, is a vasodilator, and increases vascular permeability. These are all features of allergic reactions and the major use for these drugs is in the symptomatic relief of allergic conditions. These drugs also have antagonist properties at muscarinic and dopaminergic receptors. These properties may well be responsible for their decongestant and antiemetic actions....

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