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Pharmacological treatment 

Pharmacological treatment
Pharmacological treatment

Borwin Bandelow

, Katharina Domschke

, and David S. Baldwin

Page of

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date: 03 August 2021

First-line treatment should be with selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs)

The treatment effect of antidepressants emerges slowly, over 2-4 weeks

Treatment should be continued for one year or more

Second-line treatments include TCAs or MAOIs

Benzodiazepines may be used in combination with antidepressants during the first weeks, before the onset of effect of the antidepressants; or in patients in whom other treatments were not effective or were not toler-ated due to side effects

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