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Coronary artery disease and myocardial infarction 

Coronary artery disease and myocardial infarction
Chapter:
Coronary artery disease and myocardial infarction
DOI:
10.1093/med/9780199559688.003.0130
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date: 14 October 2019

Introduction 302

Mendelian disorders associated with coronary artery disease 303

Candidate gene studies 304

The main causal and treatable risk factors for coronary artery disease (CAD) and myocardial infarction (MI) are hypertension, hypercholesterolaemia or dyslipidemia, diabetes mellitus, and smoking.

Twin and family studies have established that CAD aggregates in families, with a family history of early-onset CAD a risk factor for the disease independent of known risk factors. The highest relative hazard of CAD-related death is seen in monozygotic twins. A history of early-onset CAD in a first-degree relative approximately doubles an individuals risk of CAD (relative risk range 1.3 to 11.3)....

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