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The role of the skeleton in the pathogenesis of vascular calcification in the chronic kidney disease–mineral bone disorder 

The role of the skeleton in the pathogenesis of vascular calcification in the chronic kidney disease–mineral bone disorder
Chapter:
The role of the skeleton in the pathogenesis of vascular calcification in the chronic kidney disease–mineral bone disorder
Author(s):

Keith A. Hruska

, Suresh Mathew

, Yifu Fang

, Imran Memon

, and T. Keefe Davis

DOI:
10.1093/med/9780199559176.003.020
Page of

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date: 10 August 2020

Considerable scientific progress in the pathogenesis of vascular calcification accrued in recent years will be reviewed in this chapter with a focus on the role of the skeleton. Factors regulating mesenchymal cell differentiation and their role in the neo-intimal calcification of atherosclerosis, and the vascular media calcification observed in CKD and diabetes will be discussed, as will the role of bone regulatory proteins in bone mineralization and vascular calcification. This will include recent studies related to the discovery of new skeletal hormones involved in regulating phosphate homeostasis, sensing skeletal hydroxyapatite precipitation, regulating calcitriol production, regulating energy production and utilization, and affecting vascular calcification. Finally, the relationship between skeletal mineralization and vascular mineralization will be discussed in terms of their links, especially through the regulation of bone formation and serum phosphate concentrations.

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