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Abnormal parathyroid gland function in CKD 

Abnormal parathyroid gland function in CKD
Chapter:
Abnormal parathyroid gland function in CKD
Author(s):

Ewa Lewin

and Mariano Rodriguez

DOI:
10.1093/med/9780199559176.003.006
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date: 25 February 2020

The abnormal function of the parathyroid glands in CKD is resulting in increased PTH biosynthesis and secretion and parathyroid cell hyperplasia. At the molecular level development of 2HPT is related to changes in CaR and VDR signaling and disturbances in the regulation of PTH mRNA. Other factors of importance for the regulation of parathyroid function and cell proliferation include some of autocrine or paracrine nature. The expression of all these factors is influenced by CKD. As such, hyperparathyroidism associated with chronic uremia results from a combination of functional and structural changes in the parathyroid glands.

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