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Regulation of parathyroid hormone biosynthesis and gene expression 

Regulation of parathyroid hormone biosynthesis and gene expression
Chapter:
Regulation of parathyroid hormone biosynthesis and gene expression
Author(s):

Tally Naveh-Many

and Justin Silver

DOI:
10.1093/med/9780199559176.003.005
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date: 07 August 2020

Parathyroid hormone (PTH) is at the centre of the intricate hormonal and cellular responses to changes in mineral metabolism. The parathyroid senses small changes in serum calcium to alter PTH secretion, which then binds to its receptor in its target tissues, the bone, and kidney to correct serum calcium. The parathyroid responds to changes in calcium, phosphate (Pi), 1,25(OH)2 vitamin D (1,25D), and fibroblast growth factor 23 (FGF23). Parathyroid cells have few secretory granules as compared with other endocrine cells and, therefore, PTH production is regulated largely at the levels of PTH gene expression and parathyroid cell proliferation. In this chapter we discuss the mechanisms of how 1,25D, calcium, Pi, and FGF23 regulate PTH gene expression.

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