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New aspects of normal bone biology 

New aspects of normal bone biology
Chapter:
New aspects of normal bone biology
Author(s):

Susan M. Ott

DOI:
10.1093/med/9780199559176.003.002
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date: 24 February 2020

Bone as a structural material must be strong enough to support the body weight and light enough for efficient movement. Some of the most important new developments in bone biology help explain the mechanisms of sensing and responding to mechanical loading. New genetic approaches combined with clinical observations have led to discoveries of signaling pathways that may eventually lead to new therapies to treat or prevent bone diseases. This chapter will focus on some recently defined factors that influence bone remodeling, with an emphasis on those that could potentially be modified to improve the bone strength.

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