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Mark H. Pollack

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date: 27 February 2021

A broad range of agents have been found to be efficacious in the treatment of generalized anxiety disorder (GAD).

Selective serotonin re-uptake inhibitors, serotonin noradrenaline re-uptake inhibitors, pregabalin, and the benzodiazepines are typical first-line pharmacological treatments.

First-line agents have been shown to be effective in the long-term and to prevent relapse.

There are few evidence-based strategies for treatment of refractory GAD, but augmentation with atypical antipsychotics, benzodiazepines, pregabalin, or cognitive-behavioural therapy may be helpful.

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