- Preface
- Contributors
- 1 The human γ-aminobutyric acid transporter GAT-2: from cloning to high throughput screening
- 2 Low throughput preclinical models for headache*
- 3 Human models: screening models
- 4 Stricter success criteria, qualitative and quantitative end-points: acute versus prevention trials
- 5 Health-related quality of life and similar end-points
- 6 Clinically relevant designs and outcome measures for acute migraine trials
- 7 Effectiveness of different steroid dosage in Tolosa–Hunt syndrome with different phenotypes: some critical points about the new International Headache Society classification
- 8 Discussion summary: Trials methodology
- 9 Inducible nitric oxide synthase and development of new migraine treatments
- 10 Mechanisms of cortical spreading depression as targets for migraine therapy
- 11 Tonabersat
- 12 Discussion summary: Nitric oxide and spreading depression modulators
- 13 Calcitonin gene-related peptide: relevance for migraine
- 14 New 5-hydroxytryptamine-related drug targets
- 15 Effect of two novel calcitonin gene-related peptide-binding compounds in a closed cranial window rat model
- 16 Vasoactive intestinal polypeptide is unlikely to be a target for headache and migraine treatment
- 17 Discussion summary: Calcitonin gene-related peptide and 5-hydroxytryptamine modulators
- 18 Migraine: from genes to pathophysiology – transgenic mouse models of migraine
- 19 KATP channels and migraine
- 20 Antiepileptic drugs and migraine
- 21 Discussion summary: Ion channel modulators and antiepileptics
- 22 Innovative drug development for headache disorders: glutamate
- 23 The modulation of TRPV1 channels by cannabinoid1 receptors
- 24 Future targets for headache therapy: prostanoids
- 25 Role of anandamide in the modulation of nitroglycerin-induced hyperalgesia: a study in the rat
- Index
(p. 43) Health-related quality of life and similar end-points
- Chapter:
- (p. 43) Health-related quality of life and similar end-points
- Author(s):
Carl Dahlöf
- DOI:
- 10.1093/med/9780199552764.003.0005
Chapter 5 discusses how migraine attacks can have a profound effect on the day-to-day life and well-being of the sufferer, specifically how in the long term, migraine may cause profound emotional changes and result in coping strategies that interfere with working, social, and family life, and many normal daily activities, as well as medications, and prevention trials.
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- Preface
- Contributors
- 1 The human γ-aminobutyric acid transporter GAT-2: from cloning to high throughput screening
- 2 Low throughput preclinical models for headache*
- 3 Human models: screening models
- 4 Stricter success criteria, qualitative and quantitative end-points: acute versus prevention trials
- 5 Health-related quality of life and similar end-points
- 6 Clinically relevant designs and outcome measures for acute migraine trials
- 7 Effectiveness of different steroid dosage in Tolosa–Hunt syndrome with different phenotypes: some critical points about the new International Headache Society classification
- 8 Discussion summary: Trials methodology
- 9 Inducible nitric oxide synthase and development of new migraine treatments
- 10 Mechanisms of cortical spreading depression as targets for migraine therapy
- 11 Tonabersat
- 12 Discussion summary: Nitric oxide and spreading depression modulators
- 13 Calcitonin gene-related peptide: relevance for migraine
- 14 New 5-hydroxytryptamine-related drug targets
- 15 Effect of two novel calcitonin gene-related peptide-binding compounds in a closed cranial window rat model
- 16 Vasoactive intestinal polypeptide is unlikely to be a target for headache and migraine treatment
- 17 Discussion summary: Calcitonin gene-related peptide and 5-hydroxytryptamine modulators
- 18 Migraine: from genes to pathophysiology – transgenic mouse models of migraine
- 19 KATP channels and migraine
- 20 Antiepileptic drugs and migraine
- 21 Discussion summary: Ion channel modulators and antiepileptics
- 22 Innovative drug development for headache disorders: glutamate
- 23 The modulation of TRPV1 channels by cannabinoid1 receptors
- 24 Future targets for headache therapy: prostanoids
- 25 Role of anandamide in the modulation of nitroglycerin-induced hyperalgesia: a study in the rat
- Index