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The management of early Parkinson’s disease 

The management of early Parkinson’s disease
The management of early Parkinson’s disease

Anthony H.V. Schapira

and Anette Schrag

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date: 09 July 2020

The development of levodopa-related motor complications is related to the dose and duration of levodopa use, the age of patient and severity of disease.

The initial use of dopamine agonists delays the onset of motor complications.

MAOB inhibitors, COMT inhibitors and dopamine agonists are all effective in treating wearing off. Modifications of levodopa use: increased dose or frequency may also be appropriate in some patients.

Amantadine is useful to reduce dyskinesias. Apomorphine or duodopa can be considered for selected patients. Surgery is beneficial for appropriate individuals.

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