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Messoud Ashina

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date: 24 September 2020

Migraine is a neurovascular disorder with a genetic component.

Migraine aura is caused by cortical spreading depression.

Migraine headache is due to activation of perivascular nociceptors and subsequent plastic changes in the central nervous system.

Nitric oxide and calcitonin gene-related peptide play a key role in pathophysiology.

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