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Neurobiology and Translational Approaches to Posttraumatic Stress Disorder 

Neurobiology and Translational Approaches to Posttraumatic Stress Disorder
Neurobiology and Translational Approaches to Posttraumatic Stress Disorder

Sheila A. M. Rauch

, James L. Abelson

, Arash Javanbakht

, and Israel Liberzon

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date: 28 October 2020

Considerable research over the past 20 years has examined biological factors involved in the development and maintenance of posttraumatic stress disorder (PTSD). Understanding of the neurobiological processes that contribute to this complex and often devastating disorder is expanding rapidly. Nevertheless, understanding of the stages of development involved (i.e., risk, onset, course and outcome) remains inadequate. Many comprehensive reviews of PTSD neurobiology have been published in the past few years. This chapter provides a selective overview with two primary goals: (1) to provide an overview that is accessible to a general audience with broad interests in the neurobiology of anxiety; and (2) to synthesize neurobiological data to move forward toward deeper understanding of PTSD.

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