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Stress, Anxiety, and Depression and the Role of Glutamate Neurotransmission 

Stress, Anxiety, and Depression and the Role of Glutamate Neurotransmission
Chapter:
Stress, Anxiety, and Depression and the Role of Glutamate Neurotransmission
Author(s):

Wendol Williams

and Gerard Sanacora

DOI:
10.1093/med/9780199395125.003.0027
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date: 07 April 2020

Although the monoaminergic hypothesis of mood and anxiety has helped to expand our understanding of mental disorders and led to the development of effective treatment strategies, dysregulation of neuroplastic processes is now recognized as a likely contributor to the to the pathogenesis and pathophysiology of many neuropsychiatric conditions. The glutamatergic neurotransmitter system serves both as a major target and effector of neuroplastic processes, and it has recently become the focus of research into the pathogenesis, pathophysiology, and treatment of mood and anxiety disorders. This chapter examines the preclinical and clinical evidence suggesting that the glutamatergic neurotransmitter system contributes to the underlying neurobiology of mood and anxiety disorders. It examines evidence that pathological changes in glial cell function and amino acid neurotransmission are associated with the pathophysiology of chronic stress, and it considers the components of the glutamatergic system as targets for drug development.

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