Show Summary Details
Page of

Stress, Anxiety, and Depression and the Role of Glutamate Neurotransmission 

Stress, Anxiety, and Depression and the Role of Glutamate Neurotransmission
Stress, Anxiety, and Depression and the Role of Glutamate Neurotransmission

Wendol Williams

and Gerard Sanacora

Page of

PRINTED FROM OXFORD MEDICINE ONLINE ( © Oxford University Press, 2020. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 28 October 2020

Although the monoaminergic hypothesis of mood and anxiety has helped to expand our understanding of mental disorders and led to the development of effective treatment strategies, dysregulation of neuroplastic processes is now recognized as a likely contributor to the to the pathogenesis and pathophysiology of many neuropsychiatric conditions. The glutamatergic neurotransmitter system serves both as a major target and effector of neuroplastic processes, and it has recently become the focus of research into the pathogenesis, pathophysiology, and treatment of mood and anxiety disorders. This chapter examines the preclinical and clinical evidence suggesting that the glutamatergic neurotransmitter system contributes to the underlying neurobiology of mood and anxiety disorders. It examines evidence that pathological changes in glial cell function and amino acid neurotransmission are associated with the pathophysiology of chronic stress, and it considers the components of the glutamatergic system as targets for drug development.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.