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Neural Circuit Mechanisms of Fear Extinction 

Neural Circuit Mechanisms of Fear Extinction
Neural Circuit Mechanisms of Fear Extinction

Blake L. Rosenbaum

, Kara K. Cover

, Huijin Song

, and Mohammed R. Milad

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date: 28 November 2020

This chapter provides an overview of fear conditioning and extinction paradigms and their role in understanding the etiology of anxiety and fear-based disorders. A brief introduction discusses the basic experimental designs used to study fear extinction in rodents and humans. The neural circuitry underlying fear conditioning and extinction is discussed in greater detail in rodent models, followed by an explanation of some of the molecular mechanisms that drive associative learning. This then carries over into the human imaging studies that have investigated a variety of brain regions implicated in fear learning. Finally, the use of fear conditioning models is examined in studies that investigate the etiology and pathophysiology of fear and anxiety disorders.

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