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Translational Perspectives on Anxiety Disorders and the Research Domain Criteria Construct of Potential Threat 

Translational Perspectives on Anxiety Disorders and the Research Domain Criteria Construct of Potential Threat
Chapter:
Translational Perspectives on Anxiety Disorders and the Research Domain Criteria Construct of Potential Threat
Author(s):

Isabelle M. Rosso

, Daniel G. Dillon

, Diego A. Pizzagalli

, and Scott L. Rauch

DOI:
10.1093/med/9780199395125.003.0002
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date: 07 April 2020

The research domain criteria (RDoC) framework forwarded by NIMH may potentially reshape psychiatry. Based on evidence that much of what is considered psychopathology actually reflects dimensional variation in normative behavior and brain function, RDoC facilitates translational work in behavior, genetics, and neuroscience. This chapter describes the rationale for taking the RDoC approach to studying pathological anxiety. Focusing on the RDoC domain of “potential threat,” it reviews basic, translational, and clinical literatures germane to threat detection and explores how the behavioral patterns and neural circuits associated with this construct encourage a dimensional, transdiagnostic approach to pathological anxiety and treatment. The chapter also highlights attention bias modification treatment as one example of a novel therapeutic intervention spanning behavioral neuroscience that targets neural mechanisms of anxiety-related attentional biases. Because RDoC encourages clinical researchers to build on rapid advances in basic science, we find much reason for optimism for the emergence of neurobiologically inspired treatments.

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