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Clinical Aspects of Obsessive-Compulsive Disorder 

Clinical Aspects of Obsessive-Compulsive Disorder
Chapter:
Clinical Aspects of Obsessive-Compulsive Disorder
Author(s):

H. Blair Simpson

and Edna B. Foa

DOI:
10.1093/med/9780199395125.003.0012
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date: 11 August 2020

Obsessive-compulsive disorder (OCD) is a chronic and disabling disorder with a lifetime prevalence of 2 to 3%. The hallmarks of OCD are recurrent intrusive thoughts, images, or urges (obsessions) that typically cause anxiety or distress, and repetitive mental or behavioral acts (compulsions). Both genetic and environmental factors are implicated in the etiology of OCD; studies in humans and animals implicate abnormalities in cortico–striatal–thalamo–cortical (CSTC) circuits in its pathophysiology. Evidence-based treatments for OCD include both pharmacotherapy with serotonin reuptake inhibitors and cognitive-behavioral therapy. This chapter reviews the clinical phenotype of OCD and presents an overview of treatment strategies.

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