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Chapter 82 

Chapter 82
Chapter 82

Eric Friedberg

and Paul Harkey

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date: 21 May 2022

Ankylosing spondylitis (AS) is an immune mediated inflammatory process highly associated with HLA-B27 antigen which is four times more common in men. Commonly, AS generally presents in patients younger than 40 years of age with chronic back pain persisting greater than 3 months. AS begins with an inflammatory cascade resulting in bony ankylosis. Potential extraosseous manifestations include acute anterior uveitis, aortitis, heart block, and interstitial lung disease.

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