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Cardiovascular Disease, Metabolic Complications and Lipodystrophy in Persons with HIV 

Cardiovascular Disease, Metabolic Complications and Lipodystrophy in Persons with HIV
Chapter:
Cardiovascular Disease, Metabolic Complications and Lipodystrophy in Persons with HIV
Author(s):

Luis F. Pereira

, Harold W. Goforth

, Esteban Martínez

, Joseph Z. Lux

, Maria Ferrara

, and Michael P. Mullen

DOI:
10.1093/med/9780199392742.003.0046
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date: 24 August 2019

The introduction of effective antiretroviral therapy has contributed to a dramatic reduction in HIV-related mortality. As patients live longer, evidence suggests an increased incidence of cardiovascular disease in persons with HIV over that among individuals who do not have HIV, thus early detection and treatment of multimorbidities and modifiable cardiovascular disease risk factors particularly in persons with HIV are needed. Several mechanisms have been proposed to explain the increased risk of cardiovascular disease, including the virus itself, antiretroviral therapy, and traditional risks factors. This chapter discusses detection and treatment of cardiovascular disease in persons with HIV, as well as metabolic complications involved, including dyslipidemia, insulin resistance, and lactic acidosis. The pathogenesis and management of HIV-associated lipodystrophy as well as its psychosocial impact are also addressed.

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