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Psychopharmacological Treatment Issues in HIV/AIDS Psychiatry 

Psychopharmacological Treatment Issues in HIV/AIDS Psychiatry
Psychopharmacological Treatment Issues in HIV/AIDS Psychiatry

Kelly L. Cozza

, Gary H. Wynn

, Glenn W. Wortmann

, Scott G. Williams

, and Rita Rein

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date: 13 July 2020

Attention to pharmacokinetics and pharmacodynamics and an understanding of intended effects, side effects, toxicities, and drug interactions are imperative when treating persons with HIV/AIDS. This chapter includes an essential review of drug interaction principles and an overview of current antiretroviral treatment (ART) and known side effects, toxicities, and drug interactions, in text and table format. The chapter concludes with a presentation of psychotropic-antiretroviral treatment issues. Most psychotropics are effective in the treatment of persons with HIV, but some, particularly the pan-inducing antiepileptics, are best avoided or at least should be very carefully monitored. Recognizing the potential for drug–drug interactions allows for more careful monitoring and for consideration of alternative treatments or precautions. Being a pharmacologically knowledgeable multidisciplinary team member can reduce morbidity and mortality in patients. An understanding of antiretroviral therapy and psychopharmacological treatment issues prevents morbidity, supports adherence to medications, and improves quality of life for persons with HIV.

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