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Metaphors and Myths 

Metaphors and Myths
Metaphors and Myths

Marco Catani

and Stefano Sandrone

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date: 18 May 2021

Five hundred years of history have led to the belief that the brain consists of billions of cells that connect to form intricate local circuits, which then combine to create complex networks. Neuroimaging makes it possible to examine the structure and function of the whole brain but reveals very little about the actions of individual cells. Microscopy and the use of electrodes make it possible to observe and probe tiny collections of cells but do not give away much of the bigger picture. Up to now these two approaches to mapping the brain have, for the most part, acted separately. But the future of the connectome may well lie between the two. The next century could see their convergence at the mesoscale level, that intermediate point where local circuits come together to form those large-scale networks that characterize the human connectome.

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