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Hormone Therapy, Mood, and Cognition 

Hormone Therapy, Mood, and Cognition
Hormone Therapy, Mood, and Cognition

Aikisha Harley

, Danielle Balzafiore

, and Tonita E. Wroolie

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date: 17 September 2021

This chapter addresses the effects of hormone therapy (HT) on depressive disorders and cognition in postmenopausal women and men in later life. Currently, there is limited and conflicting evidence regarding the use of HT for depression and the prevention of cognitive decline. HT use alone may be beneficial in the treatment of mild depression and may augment and/or accelerate treatment response to antidepressants with more significant levels of depression. In general, studies suggest that HT use may provide protection from cognitive decline and Alzheimer’s disease when prescribed during menopause transition or early postmenopause, whereas HT use in late postmenopause may be problematic. Risks versus benefits of HT use need to be considered.

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