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Potential Use of Plant Adaptogens in Age-Related Disorders 

Potential Use of Plant Adaptogens in Age-Related Disorders
Chapter:
Potential Use of Plant Adaptogens in Age-Related Disorders
Author(s):

Alexander Panossian

and Patricia L. Gerbarg

DOI:
10.1093/med/9780199380862.003.0013
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date: 07 April 2020

Plant-derived adaptogens are extracts containing metabolic regulators that enable cells and organisms to adapt to a multitude of stressors. They show promising benefits in age-related disorders including fatigue, age-associated cognitive decline, neurodegeneration, hypoxia/ischemia, cardiovascular disease, and cancer. This chapter highlights the effects of adaptogens on key mediators of stress response and adaptation, and reviews clinical studies relevant to aging. The modulation of two longevity pathways (HSF1 and FOXO), membrane receptors, apoptotic signaling protein, stress-activated protein kinase, and antioxidant activity by adaptogenic herbs—R. rosea, S. chinensis, and E. Senticossus—provide a unique opportunity to preserve cellular repair and defense systems for improving longevity and quality of life.

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