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Steroids for Acute Bacterial Meningitis 

Steroids for Acute Bacterial Meningitis
Chapter:
Steroids for Acute Bacterial Meningitis
Author(s):

Robert J. Claycomb

DOI:
10.1093/med/9780199377527.003.0008
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date: 17 September 2019

This chapter provides a summary of a landmark study in neuroinfectious disease. Do intravenous steroids in combination with appropriate antibiotic therapies improve neurological outcomes in adults with likely bacterial meningitis? Starting with that question, it describes the basics of the study, including funding, study location, who was studied, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. This study demonstrated that adjunctive dexamethasone therapy is associated with improved neurological outcomes for patients with likely bacterial meningitis, particularly S. pneumoniae, and is not associated with any clinically significant adverse events. The chapter briefly reviews other relevant studies and information, and concludes with a relevant clinical case.

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