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Adjusted-Dose Warfarin for Stroke Prevention in High-Risk Atrial Fibrillation Patients: The SPAF III Trial 

Adjusted-Dose Warfarin for Stroke Prevention in High-Risk Atrial Fibrillation Patients: The SPAF III Trial
Chapter:
Adjusted-Dose Warfarin for Stroke Prevention in High-Risk Atrial Fibrillation Patients: The SPAF III Trial
Author(s):

Daniel C. Brooks

DOI:
10.1093/med/9780199377527.003.0047
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date: 16 September 2019

This chapter provides a summary of a landmark study in vascular neurology. Is the combination of aspirin and low-intensity, fixed-dose warfarin as efficacious and safer than adjusted-dose warfarin in the prevention of stroke in patients with atrial fibrillation? Starting with that question, it describes the basics of the study, including funding, study location, who was studied, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. Researchers found that adjusted-dose warfarin with an international normalized ratio of 2.0–3.0 was more efficacious than low-intensity, fixed-dose warfarin plus aspirin in preventing stroke in patients with atrial fibrillation. The chapter briefly reviews other relevant studies and information, and concludes with a relevant clinical case.

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