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IV Thrombolysis 3 to 4.5 Hours after an Acute Ischemic Stroke: The ECASS III Trial 

IV Thrombolysis 3 to 4.5 Hours after an Acute Ischemic Stroke: The ECASS III Trial
Chapter:
IV Thrombolysis 3 to 4.5 Hours after an Acute Ischemic Stroke: The ECASS III Trial
Author(s):

Michael E. Hochman

DOI:
10.1093/med/9780199377527.003.0035
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date: 18 September 2019

This chapter provides a summary of a landmark study in vascular neurology. Is alteplase effective when given 3 to 4.5 hours after the onset of an acute ischemic stroke? Starting with that question, it describes the basics of the study, including funding, study location, who was studied, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. The trial established that thrombolysis with alteplase given up to 4.5 hours after the onset of stroke symptoms is modestly efficacious; however, patients treated within the first 1.5 hours still have the best outcomes. The chapter briefly reviews other relevant studies and information, and concludes with a relevant clinical case.

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