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Continuous Dopamine Agonist for Restless Legs Syndrome 

Continuous Dopamine Agonist for Restless Legs Syndrome
Continuous Dopamine Agonist for Restless Legs Syndrome

Ashish L. Ranpura

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date: 12 July 2020

This chapter provides a summary of a landmark study in sleep. Does continuous dopaminergic therapy offer symptomatic and functional benefits to patients with restless legs syndrome? Starting with that question, it describes the basics of the study, including funding, study location, who was studied, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. It demonstrated that treatment with 24-hour rotigotine patches provided significant symptomatic relief within 4 weeks, and that this effect was durable for at least 6 months, although dose-dependent side effects tempered results. Patients with mild RLS and few daytime symptoms would be better served by conservative management and more traditional short-acting oral agents. The chapter briefly reviews other relevant studies and information, and concludes with a relevant clinical case.

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