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Modafinil for Narcolepsy 

Modafinil for Narcolepsy
Chapter:
Modafinil for Narcolepsy
Author(s):

Abeer J. Hani

DOI:
10.1093/med/9780199377527.003.0029
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date: 15 September 2019

This chapter provides a summary of a landmark study in sleep. Does daily modafinil safely decrease the excessive daytime sleepiness associated with narcolepsy? Starting with that question, it describes the basics of the study, including funding, study location, who was studied, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations for two separate dosages of modafinil. Based on study results, researchers concluded that for patients whose narcolepsy is poorly controlled by other stimulants, modafinil is effective and well tolerated. A 200 mg dose has similar efficacy to a 400 mg dose and fewer side effects. The chapter briefly reviews other relevant studies and information, and concludes with a relevant clinical case.

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