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Steroids for Acute Optic Neuritis: The Optic Neuritis Treatment Trial 

Steroids for Acute Optic Neuritis: The Optic Neuritis Treatment Trial
Chapter:
Steroids for Acute Optic Neuritis: The Optic Neuritis Treatment Trial
Author(s):

Mary A. Bailey

DOI:
10.1093/med/9780199377527.003.0027
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date: 22 September 2019

This chapter provides a summary of a landmark study in neuro-ophthalmology. Is there a benefit to treating acute optic neuritis with either oral corticosteroids alone or intravenous followed by oral corticosteroids? Starting with that question, it describes the basics of the study, including funding, study location, who was studied, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. This study concluded that treatment with IV methylprednisolone followed by oral prednisone for acute optic neuritis had better outcomes at 6 months than placebo and oral prednisone–only groups. The chapter briefly reviews other relevant studies and information, and concludes with a relevant clinical case.

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