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Oral versus IV Steroids for Acute Relapses of Multiple Sclerosis 

Oral versus IV Steroids for Acute Relapses of Multiple Sclerosis
Chapter:
Oral versus IV Steroids for Acute Relapses of Multiple Sclerosis
Author(s):

Joshua Lovinger

DOI:
10.1093/med/9780199377527.003.0011
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date: 19 September 2019

This chapter provides a summary of a landmark study in multiple sclerosis. Are oral steroids as effective as intravenous steroids in treatment of acute relapses of multiple sclerosis? Starting with that question, it describes the basics of the study, including funding, study location, who was studied, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. Oral steroids appear to be equally efficacious in treating MS exacerbations relative to IV steroids, are considerably cheaper, and do not require hospital admission; however, due to concerns about higher rates of recurrent optic neuritis with oral versus IV steroids, some continue to prefer IV treatment for exacerbations. The chapter briefly reviews other relevant studies and information, and concludes with a relevant clinical case.

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